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Un-protonated nicotine is rapidly absorbed in the mouth, and the rate of absorption is a primary factor of addiction for nicotine, as it is for other substances 33,34

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However, it usually trades at a slight premium to its former parent

This may partly explain the dramatic increase in Syn-S129p levels from ~4% under physiological conditions to ~90% in pathological conditions 5,31,32,87,88