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SURMOUNT-5 resolved the question definitively

The triple mechanism is what distinguishes it from dual (tirzepatide) and single (semaglutide) agonists

Glucose Control A clinically studied probiotic shown to nutritionally help lower post-meal blood sugar and A1C levels in people with type 2 diabetes.** Polyphenol Booster A targeted prebiotic that feeds and boosts Akkermansia muciniphila

Lancet 2020

A statistically significant increase in thyroid C-cell adenomas was observed in males and females at all dose levels, and a statistically significant increase in thyroid C-cell carcinomas was observed in males at greater than or equal to 0.01 mg/kg/day, at clinically relevant exposures

Danielle S
