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[3] In 17th-century France, the leaves of the tobacco plant were thought to have wide-ranging medicinal properties and physicians used it to treat bubonic plague, asthma, cancer, migraine and for pain relief during childbirth

Although interactions between pharmacokinetic drugs and tobacco smoke are primarily attributed to PAHs rather than nicotine, the latter is significantly involved in pharmacodynamic interactions through the activation of the sympathetic nervous system (Benowitz, 1997)

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[29] : Ch.6&7 One major Indian company gives annual bravery awards in its own name

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