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Recently, it has been shown that even at a 10:1 ratio, nicotine does not have a significant effect on A and its aggregation pathway and may affect A amyloid burden by affecting A production, degradation, or/and localization [205]

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However, current e-cigarette use increased 78% among high school students during the past year, from 11.7% in 2017 to 20.8% in 2018