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[12] [10] If this is true, cotinine would facilitate endogenous neurotransmission without directly stimulating nAChRs

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Graphical Abstract Similar content being viewed by others Introduction Electronic nicotine delivery systems (ENDS), commonly known as electronic (e-) cigarettes or vapes, are battery-powered devices that deliver aerosol, containing nicotine and other constituents such as propylene glycol, vegetable glycerin, and flavorings, classified by regulatory agencies as tobacco products [1]