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Nicotine is a strong stimulant that releases adrenaline and narrows blood vessels

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[DOI] [PubMed] [Google Scholar] Stead 2012 Stead LF, Perera R, Bullen C, Mant D, HartmannBoyce J, Cahill K, et al

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From Humble Beginnings The Cigarettes item was initially never supposed to make it into the first Metal Gear due to how it might affect the game's age rating