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Chronic Effects Smoke exposure can injure the victim immediately (acute onset) or over a longer period of time (chronic/delayed onset)

Management focuses on improving circulation and upright tolerance through hydration, conditioning, and medical supervision, rather than directly targeting the brain

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doi:10.1093/ije/30.1.35

Yes, potential side effects include hiccups, jaw discomfort, indigestion, and mouth irritation

Nicotines stimulating properties involve increasing the production of certain chemicals in the brain, which can inadvertently lead to an increased frequency of bowel movements for some people