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EVIDENCE SUMMARY Bupropion is the only Food and Drug Administration (FDA)-approved antidepressant recommended as a first-line pharmacologic agent to assist with smoking cessation, based in part on a meta-analysis of 44 placebo-controlled RCTs (13,728 patients), which found that bupropion had a relative risk (RR) of 1.62 for smoking cessation compared with placebo (95% confidence interval [CI], 1.49-1.76)

Use a mixture of baking soda and vinegar, followed by boiling water

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Findings over a 15-year period

According to Ledgerwood, this and other variables explain why so many smokers find it difficult to quit

Users need to ask questions about nicotines effects on their heart