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Smoked cigarette butt leachates from 19 different brands of smoked cigarette butts were found to be toxic to Ceriodaphnia dubia at concentrations between 8.9 and 25.9 mg butts/L (48-hour EC50 (immobilization) and to Vibrio fischeri at concentrations between 104 and 832 mg butts/L (30-minute EC50 [bioluminescence])

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Still, lung cancer and smoking death rates are lower than in the United States where less people smoke

Smoking is a leading cause of cancer and is absolutely preventable

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Similarly, ROS induced in the lung as a result of tobacco smoke exposure also activate the NFE2-like bZIP transcription factor 2 (NRF2) pathway (63), which has been shown to upregulate the PPP (64), potentially linking tobacco smoke exposure to inflammation-associated metabolic reprogramming that may contribute to CR production