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In a key paper from 2012 it was the largest and longest-running study to date, testing 1,037 people at age 13 and 38 scientists at Duke University found a dramatic drop in intelligence among long-term marijuana users suggestive of a neurotoxic effect of cannabis on the adolescent brain, they wrote in PNAS

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Although the final text does not include any specific reference to health over trade, the first line of the Convention's preamble states, The Parties to this Convention, determined to give priority to their right to protect public health. The general objective of FCTC, and this wording in particular, could be interpreted as intending to allow strong domestic tobacco control measures, even if there are adverse consequences that affect trade and may make international trade and investment agreements more sensitive to tobacco control (WHO 2012a)

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