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Menthol also interacts with nicotine in the brain to enhance the addictiveness of nicotine, making it harder for people to quit smoking, explained Rachel Grana Mayne, Ph.D., a program director in NCI's Tobacco Control Research Branch

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Also, take note if the supplements are best taken with food or on an empty stomach

Epidemiological study of constipation and other gastrointestinal symptoms in 8000 children