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See also p.29 of the report: Burning Issues: The Global State of Tobacco Harm Reduction 2020 Difference Between Levels of Adult Tobacco Smoking for Males and Females - Burning Issues: The Global State of Tobacco Harm Reduction 2020 Average levels of smoking at a national level hide significant differences in the levels of smoking between males and females

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[19] Finally, biological factors such as initial sensitivity to nicotine, exposure to smoking during prenatal development, nicotine metabolism, and genetic susceptibility have been linked to the development of APESCGIT in smoking cessation individuals

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A 2026 preprint study published via medRxiv Oral Nicotine Pouch Use Among U.S