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E-cigarettes contain nicotine which is highly addictive and can harm adolescent brain development, which continues into the early to mid-20s

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By addressing the challenges posed by these products, clinicians can optimize outcomes while fulfilling their ethical and medicolegal obligations

Nicotine also stimulates sensory and parasympathetic nerves from the gastrointestinal (GI) tract, increasing fluid secretion and peristalsis and interacting with the nicotinic receptors in the central nervous system (CNS) and post-synaptic autonomic ganglia, causing CV fluctuations, weakness, and CNS excitement

Connections with mental health Cannabis use is associated with depression in young adults and is associated with earlier onset and worse symptoms of psychotic illness, including schizophrenia

Other systemic toxicity A meta-analysis of four in vivo studies conducted by PMI researchers assessed the impact of IQOS on the activity of the cytochrome P450 1 A2 (CYP1A2) enzyme responsible for the metabolism of harmful xenobiotics like amines