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The figure depicts the major established pathways of cancer causation by cigarette smoking: (1) the exposure to carcinogens (cancer-causing substances), (2) the formation of covalent bonds between the carcinogens and DNA (DNA adduct formation), and (3) the resulting accumulation of permanent somatic mutations in critical genes (genes appear in italics)

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Circa: 1920's

Mild Quantity: Box of 50 Cigars Total Flavor: Natural Strength: Mellow Shape: Cigarillos Length: 5 Inches Ring: 30 Rings Wrapper Type: Homogenized Tobacco Leaf Binder: Homogenized Tobacco Leaf Made in: United States