how did tobacco start History of Tobacco smoking - Wikipedia
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US, Surgeon General's Advisory Committee on Smoking and Health (1964) Smoking and Health

3 When used appropriately, traditional tobacco is not associated with addiction and adverse health impacts

Zhonghua Nan Ke Xue

The contents of nornicotine, anabasine, NNN, NNK, NAT, total TSNAs and the nicotine of mainstream cigarette smoke decreased, and the contents of amino acids and the precursors of alkaloids increased in grafted tobacco

Intake of vitamins E, C, and A and risk of lung cancer

Of these, about 3.3 million are producers, nearly 6 million are unpaid family members, and the rest are considered temporary laborers
