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A measure of secondhand smoke exposure and active smoking is cotinine, nicotines primary metabolite ( Definition of constipation To diagnose constipation, stool frequency and consistency were considered important factors based on the Rome IV criteria ( Covariates In accordance with the literature, a variety of potential covariates were assessed ( Statistical analysis The means (standard deviations) and medians (interquartile ranges) were calculated and compared for continuous variables using either the Students t-test for normal distribution or the MannWhitney U-test for non-normal distribution

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