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Patients with cannabinoid hyperemesis syndrome (CHS) may get a warning phase with nausea, decreased appetite and vague abdominal pain which can last for days before developing repetitive vomiting and diffuse abdomen pain
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Incapsula incident ID: 278000700157619057-440139070167191952

Scientists found significant decreases in the sensitivity of the brains of laboratory rats to pleasurable stimulation after nicotine administration was abruptly stopped

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