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Murphey, Rhoads (2007)

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Everett Koop used his bully pulpit to rally public support for anti-smoking measures, such as in these remarks at a press conference: If you look at the biomedical literature of the past 30 years, you have to be impressed with the extraordinary amount of evidence that has been generated to prove the causal relationship between cigarette smoking and some two dozen disease conditions

For example, acrolein is an intense pulmonary irritant and toxicant, causes neurogenic inflammation, airway hypersensitivity, and is proposed to be a pulmonary carcinogen