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As a short-chain fatty acid, ALA can both be absorbed by fatty tissues and maintain its solubility in water, allowing it to be easily excreted from the body when not needed

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We investigated the longstanding idea that the onset of psychotic symptoms in schizophrenia arises from an early phase of glutamate neurotoxicity, possibly related to loss of GABA restraint, oxidative stress or inflammation, that cumulatively results in a later phase of synaptic loss in keeping with magnetic resonance spectroscopy (MRS) evidence of reduced glutamate in schizophrenia, especially in older patients
Eur J Clin Invest 2000 Oct;30(10):841-2. [PMID: 11029607]
