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Directions: Dosage: 14mg Instructions: To Increase Your Success in Quitting: 1. You must be motivated to quit. 2. Complete the full treatment program, applying a new patch every day. 3. Use with a support program as described in the enclosed User's Guide. NDC: 0135-0195-02
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Dermatology 2005;211:118122

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And some of those may be released in smaller amounts
As a relative risk, 20% could be high or low depending on which reference group was used