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And research published in JCI Insight reveals something fascinating: tirzepatide shows an "imbalanced" affinity, engaging GIP receptors more strongly than GLP-1 receptors while producing biased signaling at the GLP-1 receptor that favors cAMP generation over beta-arrestin recruitment

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SGLT2 and SGLT2is The sodium-glucose cotransporter 2 (SGLT2) is located in the apical membrane of the S1 and S2 segments of the proximal tubule and is responsible for 90% of glucose and sodium reabsorption [83]

Now, if we think about this in the context of the GLP-1 phase 3 trials for weight management purposes, those range from weight loss of approximately 8% at 1 year all the way up to almost 20% with tirzepatide, which is also known as Mounjaro or Zepbound