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Taxing based on nicotine content would favor low-nicotine liquids and could encourage increased consumption in the quantity of liquid
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This correlation has driven research into nicotines effects on dopaminergic pathways and inflammatory processes that contribute to neuronal loss in the substantia nigra

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Moreover, studies show tobacco use is a relevant risk factor for stroke, cerebral aneurysms, subarachnoid haemorrhage (relative risk, 2.93