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The amount of AEA and 2-AG that reach and activate CB 1 R/CR 2 R is regulated by at least five mechanisms: 1] enzymes that produce eCBs, 2] eCB transport from their synthesis to their target receptors, which involves fatty acid binding proteins, 3] the number of functional CB receptors at the membrane and their biased signaling, 4] the clearance of eCBs by uptake through the plasma membrane and 5] eCB inactivation by enzymatic hydrolysis

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Were silent except for the televisions drone, and then he chuckles, exhaling