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Arterial nicotine kinetics during cigarette smoking and intravenous nicotine administration: implications for addiction

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24 weeks total) are unlikely to provide any additional benefit on average, 19 and would not be funded under the Special Authority criteria

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This finding is in agreement with other studies showing a low plasma uric acid in regular smokers [14] and a reduction of antioxidants, including uric acid, in smokers, indicating that oxidative stress increases each time a cigarette is smoked [15, 16]