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Smoking paralyzes and damages these cilia, leaving your airways vulnerable to irritants and infections Side Effects of Smoking Cigarettes: Chronic Obstructive Pulmonary Disease (COPD): Smoking is the leading cause of COPD, a progressive and debilitating condition that includes chronic bronchitis and emphysema

People who have COPD are strongly advised to stop smoking - it's the "most important thing you can do".

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In addition, the FDA assesses whether a given product would offer more benefits than risks to the general population, considering the population as a whole , including users and nonusers of tobacco products