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Studies have consistently demonstrated a distinctive microbial profile in smokers, characterized by higher levels of key periodontal pathogens such as Porphyromonas gingivalis and Treponema denticola , and a concurrent loss of beneficial or health-associated microbial species

[DOI] [PMC free article] [PubMed] [Google Scholar] [20].Pryor WA, Cigarette smoke radicals and the role of free radicals in chemical carcinogenicity, Environ Health Perspect, 105 Suppl 4 (1997) 875882

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But if you use them repeatedly, you may feel the need to raise your dose to have the same effect or to perform sexually

2018 ACC expert consensus decision pathway on tobacco cessation treatment: a report of the American College of Cardiology Task Force on Clinical Expert Consensus Documents