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doi: 10.3389/fcell.2021.722412 123 GaoTZhangXZhaoJZhouFWangYZhaoZet al

Critical appraisal of the current phytochemical evidence in PCOS While a wide variety of phytochemicals have demonstrated potential in treating PCOS, the quality of evidence varies depending on the compound and type of study

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Over time, cortisol levels can drop after they are high for prolonged periods of time

In Alzheimers disease, PHGDH upregulation, an upstream control point in the serine synthesis pathway, supports the idea that disrupted serine metabolism is coupled to persistent neuroinflammatory signaling 73

Ferroptosis, a recently documented form of programmed cell death caused by iron-induced lipid peroxidation, has been implicated in the pathogenesis of several neurodegenerative retinal diseases [1], such as glaucoma [1, 6], inherited retinal dystrophies [7], and age-related macular degeneration (AMD) [8,9,10]