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10.3945/ajcn.111.021543 7

Its action on GIP and GLP-1 receptors enhances appetite control and metabolic function, suggesting higher efficacy compared to single GLP-1RAs

Importantly, these medications carry a boxed warning about the risk of thyroid C-cell tumors and are contraindicated in patients with a personal or family history of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN2)

Nutritional Deficiencies Eating less can sometimes mean missing important nutrients

The mechanism by which GLP-1RAs induce reduction of body weight and hunger is believed to relate to multiple mechanisms by which GLP-1 regulates appetite and energy consumption and supports metabolic homeostasis via central neuronal pathways and through neuronal activation in the gastrointestinal tract [94, 141]

That data simply does not exist