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Ishizaka N, Ishizaka Y, Toda E, Shimomura H, Koike K, Seki G, Nagai R, Yamakado M

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Consistent with these findings, adoptive transfer studies have demonstrated that cigarette smoke exposure selectively enhances the proinflammatory properties of Th17 cells and the immunosuppressive activity of Treg cells through a GPR15-dependent mechanism, underscoring GPR15 as a central regulator of divergent T-cellmediated immune responses to environmental factors in colitis

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