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[DOI] [PubMed] [Google Scholar] Falkow S (1988)

L-cysteine is an essential component of the protein and can be synthesized from serine or methionine in animals

In summary, clarifying the link between the gut-joint axis and ferroptosis in OA would be of great significance not only for better understanding the pathological processes at multi-levels (local joint tissues, the gut environment, and circulation), but also from a unique angle for guiding novel therapies development in OA Deep investigative approach to understand how major gut bacterial metabolites (tryptophan-derived metabolites, TMAO and so on) modulate ferroptosis in OA is very promising to elucidate the central regulatory mechanism acted by the gut-joint axis on ferroptosis in OA

After 23 h of incubation, the supernatants were removed, and a luciferase detection reagent (100 L/well) was added

Poyner, D