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Micro : Insert the filter from the top, then rotate it until it locks into place

This is achieved by releasing controlled amounts of nicotine into the bloodstream, which then stimulates the release of dopamine, mimicking the pleasurable sensations associated with smoking and the effects of an addictive substance

Changing how you consume it drastically alters how your body processes the drug

Prolonged or repeated exposure may cause dermatitis and may damage the liver and kidneys

Legislation a few years ago froze the tobacco tax in each county so no changes could be made

Reporting summary Further information on research design is available in the Nature Research Reporting Summary linked to this article