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Nicotine satisfaction is closely related to the protonated and free states of nicotine in the blood ( In conclusion, we observed the pharmacological effects of multiple nicotine salt e-cigarette exposures on brain DA release using animal models that partially simulate human smoking behavior using in vivo fluorescence imaging techniques and found differences in the effects of multiple nicotine salts, providing a new experimental basis for understanding the pharmacological effects of nicotine salts

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