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According to a 2006 study, nicotine interacts with digestive tract smooth muscle contractions (peristalsis)

However, the funniest one of all comes when he uses an iron boot

JAMA 1998

Platinum-based chemotherapy consisting of either cisplatin or carboplatin is the usual first-line treatment for inoperable recurrent or metastatic HNSCC 5

In short then he seems to be saying that if you take just one shot of this highly addictive drug (after which you will almost certainly become addicted) then that first, initial dose might somehow provide some kind of benefit, perhaps in concentration (Id dispute even that flimsy suggestion)

These are signs that the tobacco has deteriorated