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Risperidone When administered concomitantly with topiramate at escalating doses of 100, 250, and 400 mg/day, there was a reduction in risperidone systemic exposure (16% and 33% for steady-state AUC at the 250 and 400 mg/day doses of topiramate)

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One blend that does require extra attention is any formulation where the total solute concentration is high enough to change the solution viscosity

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