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Smoke induced cell death of airway cells has been hypothesized 3 to play a role in both airway remodeling and inflammation contributing to disease progression 4

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Phantosmia can feel distressing and may get in the way of daily life

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Lung cancer rates in the United States are high, with over 200,000 newly diagnosed lung cancer patients and survivors throughout the country

Many toxic effects induced by CS, particularly the induction of carcinogenesis, result from direct genetic or epigenetic effects resulting in altered gene functions (for example, cell cycle, DNA repair, and tumor suppressor genes)