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The Nrf2sMAF heterodimer binds to the antioxidant response element (ARE), which leads to the transcription of genes encoding antioxidant and detoxification enzymes such as SOD, CAT, GP X , heme oxygenase 1 (HO-1), NAD(P)H quinone dehydrogenase 1 (NQO1), which protect cells from oxidative stress and toxins (124126) (Figure 3)

IIDs can also malfunction, thus causing a false positive
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"A qualitative content analysis of cigarette health warning labels in Australia, Canada, the United Kingdom, and the United States." American journal of public health 105.2 (2015): e61-e69
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Participants attached labels to each cigarette pack they finished, filled in the required information and posted them back to the research agency at the end of each week