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this represents the most recent time period since the last systematic review of the available evidence for the GBD at the time of publication

Nicotine, heroin, cocaine, methamphetamine, and alcohol are consistently identified in research as having the highest addiction liability based on factors including dependence rate among users, withdrawal severity, and the difficulty of sustained abstinence

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As of 2014, it is outlined in the Code of Virginia (section 22.1-79.5) that it is illegal to use e-cigarettes on school property, including school buses and school sponsored activities

Connections of nicotine to cancer