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The elderly and young populations, as well as people with chronic illnesses, are especially vulnerable to the adverse effects of smoking

Neutrophils are the primary source of two tissue-damaging factors myeloperoxidase and neutrophil elastase

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The Mayo Clinic recommends NRT (patches, gum, lozenges) as a first-line treatment, with prescription options like varenicline for people who need additional support

NHS Stop Smoking Services offer nicotine replacement therapy, prescription medications, and behavioural support with high success rates

Currently, it is recommended that all patients with liver disease be offered pharmacologic and psychologic smoking cessation resources, particularly patients being considered for liver transplantation