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S., Monterosso, J., Simon, S., Jarvik, M., et al

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Under these conditions, RNA-derived donors supported R2-mediated integration into genomic rDNA without DNA donor intermediates, providing evidence consistent with a temporally constrained, RNA-based insertion framework in plants

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Although counterintuitive, these findings coincide with previous work in cell culture which demonstrates an exaggerated complement deposition and CD35 expression on endothelial cells following treatment with nicotine-free formulations when compared to nicotine-containing counterparts (Barber et al., 2017