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Description
Epigenetics is usually defined as heritable alterations in gene expression patterns that are not directly caused by modifications encoded in the nucleotide genome sequence but are caused by posttranslational modifications in DNA and histone proteins and by the regulation of non-coding RNAs (ncRNAs) [6]
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This plaque turns into a hard substance called calculus or tartar

They are approximately 3000 years old and were probably used for smoking cannabis
643828 Proctor RN

Table 1)
