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Code year: FY2026 (Oct 1 2025 Sep 30 2026) Audience: Certified Coders, Auditors and Clinical Documentation Specialists Access: CCO Members Last updated: April 2026 Definition Drug dependence (substance use disorder) is a chronic, relapsing brain disease characterized by compulsive drug seeking and use despite harmful consequences, driven by neurobiological changes in reward, stress, and inhibitory control circuits