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Wtp53 recognizes and binds to DNA response elements (RE), then recruits TFs, histone acetyltransferases (HATs) such as p300, chromatin remodeling complexes (CRCs) such as SWI and SNF that bind to acetylated histones [21, 55], and RNA polymerase II, which binds to open promoters to form the pre-initiation complex (Fig