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Additionally, a calcitriol-elicited downregulation of the anti-apoptotic BCL2 and BCLXL and overexpression of the pro-apoptotic BAX, BAK , and BAD genes have also been described [147]
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hence, they considered that it might be a possible mechanism that hepatocytes would differentiate into hepatoma cells, because the p53-dependent damaged DNA repairing pathway was blocked, and the functions of key tumor-suppressor genes of hepatocytes were abolished 56
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'Stop completely' Cardiovascular disease, not cancer, is the greatest mortality risk for smoking, causing about 48% of smoking-related premature deaths
