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In the Hartwig Medical Foundation cohort, which included 178 patients with lung cancer 186 , various nonsense, frameshift or splice site-altering germline variants were found in CHEK2 and Fanconi anaemia complementation group (FANC) genes ( FANCI, FANCL, FANCM ), involved in DNA repair, as well as DOCK8 and GJB2 (encoding dedicator of cytokinesis protein 8 and gap junction 2 protein, respectively)