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Nicotine is classified as a pharmaceutical agent in Japan under the Pharmaceuticals and Medical Devices Act (Act on Securing Quality, Efficacy and Safety of Pharmaceuticals, Medical Devices, Regenerative and Cellular Therapy Products, Gene Therapy Products, and Cosmetics)

The absence of nicotine and tobacco does not eliminate the risks associated with inhaling smoke, which can damage lungs and increase cardiovascular problems

Available from Begg S, Vos T, Barker B, Stevenson C, Stanley L and Lopez AD, 2007

[DOI] [PMC free article] [PubMed] [Google Scholar] 98

Over time, the smokers brain develops less of a response to nicotine due to the high concentrations

In general, however, these treatments have had limited success compared to treatments delivered in community settings