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The study found a significant decrease in carnitine concentrations in semen samples obtained from infertile men diagnosed with oligoasthenoteratozoospermia [175]

On the other hand, another study found no effect of 2000 mg NR per day supplementation in obese or overweight men on NAD + metabolite or mitochondria in skeletal muscle, although muscle NAMPT levels were decreased 316

This dyslipidemia is partly due to hepatic insulin resistance, which impairs the suppression of hepatic glucose production and enhances very low-density lipoprotein (VLDL) secretion (Jahdkaran and Sistanizad, 2025)

Acknowledgements The work of the authors cited in this review was partially supported by the Institut National de la Sant et de la Recherche Mdicale (INSERM), the Conseil Rgional de Bourgogne, and the Universit de Bourgogne