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Front Genet (2013) 4:132.10.3389/fgene.2013.00132 72 FreemanJRChuSHsuTHuangYT

Although the previous studies have reported the intermediate degradation products and metabolic mechanisms of nicotine in the different strains, the comprehensive pathways, metabolic mechanisms and associated genes involved in the degradation of TSNA, -carotenes, starch, protein and other compounds in tobacco microorganisms remain to be elucidated

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21 nAChR is made of 17 subunits in mammals including (1-7, 9, 10, 1-4, , and ) that are encoded by 17 different genes

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