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Although serious GI tract ulcerations and bleeding can occur without warning symptoms, patients should be alert for the signs and symptoms of ulcerations and bleeding, and should ask for medical advice when observing any indicative signs or symptoms including epigastric pain, dyspepsia, melena, and hematemesis
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The harmful chemicals in tobacco smoke damage collagen and elastin which are fibres that gives skin its strong, elastic properties

Additionally, the chemical substances in cigarettes cause gum irritation, reduced blood circulation, and gum recession

As of 2018, this number had increased to 3.2 million
