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The shorter telomere of the smokers chromosome reflects premature aging of about 5 years, and increases the risk of cancer

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This includes members of two different CDK suppressor protein (CKI) families associated with CDK (Sherr and Roberts, 1999): One is the INK4 (Inhibitor of CDK4) protein family, such as p15, p16, etc., which specifically binds to CDK4/6 kinase and prevents their interaction with D-type cyclin

Results In Table 1, we display descriptive information and operational definitions for all variables included in the analysis

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