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Sample analysis of nicotine and cotinine Sample analysis was processed by the modified method of Massadeh et al

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In addition to nicotine, e-cigarette vapor includes potentially harmful substances such as diacetyl (a chemical linked to a serious lung disease), cancer-causing chemicals, volatile organic compounds and heavy metals such as nickel, tin, and lead

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In this literature review, we highlight studies that have investigated the impact of E-cigarette vapour and its major constituents on bone, detailing the models utilised and the mechanistic and functional results regarding bone health (Table 1)